Formulation & Comparative Evaluation of Rapid Disintegrating Tablets of Diclofenac Sodium Using Sodium Starch Glycolate as A Synthetic Superdisintigrant

Vivek D. Rathod; Sourabh V Khadse

Volume : VII, Issue : II, February - 2018

Formulation & Comparative Evaluation of Rapid Disintegrating Tablets of Diclofenac Sodium Using Sodium Starch Glycolate as A Synthetic Superdisintigrant

Vivek D. Rathod, Sourabh V Khadse

Abstract :

The aim of the present work is to formulate a tablet which disintegrate and dissolve rapidly and give its rapid onset of action: analgesic, antipyretic and anti–inflammatory action. Diclofenac sodium is among the most extensively used NSAIDs; employed in musculoskeletal complaints, especially arthritis. Conventional diclofenac sodium tablet available in market are not suitable where quick onset of action is required. In present study, an attempt had been made to formulate for RDT of diclofenac sodium by using various superdisintigrant like sodium starch glycolate, followed by direct compression technique to develop formulations of diclofenac sodium Rapid dispersing tablets, in the present study it was propose to formulate an oral delivery system, in the form of Rapid dispersing tablet of diclofenac sodium, sodium starch glycolate and their combinations in different ratios.