FORMULATION AND EVALUATION OF A POLYHERBAL: CURCUMIN AND BOSWELLIA LOADED ETHOSOMAL GEL

Pranay Wal; Ruchi Tiwari; Priya Singh

Volume : IX, Issue : VI, June - 2020

FORMULATION AND EVALUATION OF A POLYHERBAL: CURCUMIN AND BOSWELLIA LOADED ETHOSOMAL GEL

Pranay Wal, Ruchi Tiwari, Priya Singh

Abstract :

Diabetic neuropathy is a chronic complication of diabetes mellitus with symptoms of decreased motility and severe pain in peripheral parts. Thus, our objective was to formulate the polyherbal ethosomal gel containing Boswellia serrata having anti–inflammatory properties and Curcuma longa that possess antioxidant, antibacterial and anti–inflammatory properties and is used in various skin creams. Ethosomes were prepared using cold method and ethosomal gels were prepared in nine different formulations, which were evaluated for its pharmaceutical properties and were assessed using gel parameters. The results showed that the gels were non–irritant and stable. Formulation NE 9 containing lipid (Soya lecithin) surfactant (Propylene Glycol) in ratio 1:2 showed highest drug entrapment efficiency. All the parameters assessed were with good physicochemical properties. Thus, the present study revealed; ethosomal gel as an efficient carrier for herbal extract.