FORMULATION OF NANOCAPSULATE GEL OF PARACETAMOL AND STUDYING ITS IN VITRO RELEASE PATTERN THROUGH DIFFERENT KINETIC MODELS

Jayanti Mukherjee; Deepak Birla; Shivani Khoware

Volume : IX, Issue : V, May - 2020

FORMULATION OF NANOCAPSULATE GEL OF PARACETAMOL AND STUDYING ITS IN VITRO RELEASE PATTERN THROUGH DIFFERENT KINETIC MODELS

Jayanti Mukherjee, Deepak Birla, Shivani Khoware

Abstract :

The paracetamol nanocapsules were prepared by the interfacial deposition technique proposed by Fessi et al using benzyl benzoate, PLGA, soyalecithin and Polaxamer. Fine concentrated colloidal dispersion of paracetamol nanocapsules were characterized by scanning electron microscopy, zeta potential and particle size analysis. The compatibility of the excipients was analysed by FTIR. The nanogel of paracetamol was formulated with carbopol 934 and triethanolamine as the major ingredients. The transdermal formulation was tested for its in vitro permeation studies through the biomimetic dialysis memane using Franz diffusion cell. The receiver solution was phosphate buffer (pH 7.4) and the permeability study was carried out for 8 hours. The in vitro release profiles were determined by plotting cumulative % drug release Vs time (Zero order release), log cumulative % drug remaining vs time (First order release), cumulative % drug release vs square root of time (Higuchi Model), log cumulative % drug release vs log time (Korsmeyer Peppas Model) and cube root % drug remaining vs time (Hixson Crowell Model). From the release kinetics data, it was observed that the release of paracetamol from the nanocapsulate gel exhibited good correlation for Korsmeyer Peppas, Zero order, Higuchi and Hixson Crowell model.