GABAPENTIN AS PRE-EMPTIVE ANALGESIC AGENT GIVEN TO ABDOMINAL HYSTERECTOMY PATIENTS FOR POST OPERATIVE ANALGESIA

Dr. A. Arivarasan; Dr. T. Saravanan

Volume : VIII, Issue : V, May - 2019

GABAPENTIN AS PRE-EMPTIVE ANALGESIC AGENT GIVEN TO ABDOMINAL HYSTERECTOMY PATIENTS FOR POST OPERATIVE ANALGESIA

Dr. A. Arivarasan, Dr. T. Saravanan

Abstract :

Background and Aims: The study was undertaken to assess the safety and efficacy of preoperative single oral dose of gabapentin for postoperative benefit in patients undergoing abdominal hysterectomy under spinal anaesthesia and to assess the other effects such as duration of analgesia with total analgesic requirement, measurement of postoperative sedation scores and side effects of oral gabapentin. Methods: Patients were randomly assigned into two groups of 30 in each. Group G received gabapentin (300 mg); Group P received a placebo orally 2 h before surgery. Sevearity of postoperative pain was analyzed by Visual Analogue Score at rest and movement, Time of rescue analgesic and by Post–operative complications. Results: On comparison, the T1 score is significantly greater in Group G (183.00 ± 19.81) compared to Group P (172.33 ± 11.50)) whereas, the total Tramadol consumption was significantly lower in Group G (221.33 ± 40.32) compared to Group P (289.00 ± 21.31). The mean Ramsay sedation scores for Group G were between 2.20±0.41 h to 2.93±0.25 h and for Group P were between 2.00±0.00 h to 2.27±0.45 h. The adverse effect such as nausea, vomiting and dizziness were noted in the ratio of 3:4, 2:2 and 1:0 in Group G and Group P patients respectively this showed there is no discrepancy in the side effects. Conclusion: Single dose of gabapentin administered 2 h before surgery provides better pain control as compared to placebo. It prolongs the duration of analgesia, reduces the total analgesic requirement during the postoperative period