HEPATITIS C VIRUS SEROPREVALNCE IN LIVER DISEASE PATIENTS AT SMS HOSPITAL AND ALLIED HOSPITALS

DR. BHUPENDRA KUMAR MANDAWAT; DR. LEELA VYAS

Volume : VIII, Issue : VI, June - 2019

HEPATITIS C VIRUS SEROPREVALNCE IN LIVER DISEASE PATIENTS AT SMS HOSPITAL AND ALLIED HOSPITALS

Dr. Bhupendra Kumar Mandawat, Dr. Leela Vyas

Abstract :

Seroprevalence of Hepatitis C virus in Liver Disease patients at SMS Hospital and Allied Hospitals. Various hepatic disorders like Hepatitis,Fulminant hepatic failure,Sub acute fulminant hepatic failure,Chronic liver diseases,Livercirrhosis,Hepatocellular Carcinoma cause multi organ failure leading to death. The most important viral cause of hepatic disorders after HBV is HCV[18]. BACKGROUND: Various Hepatic disorders caused by HBV and HCV have become a major public health problem throughout the world. HCC is one of the ten most common cancers in the world and is the only cancer which can be prevented by vaccination[7]. HCV infection can be transmitted by blood transmission, injectable drugs, perinatally, improperly sterilized dialysis equipment, unprotected sex with infected partner specially MULTIPLE SEXUAL PARTENER groups detection and treatment and its prevention in community[25] OBJECTIVES:To find out the seroprevalence of anti HCV antibodies in various categories of Liver Disease patients from different OPDS, wards and ICUs of SMS Hospital and J.K. Loan, MahilaChikitsalaya and Zanana Hospital Jaipur etc.This study is conducted to aid in early detection & treatment & its prevention incommunity.METHODOLOGY:The study is conducted in the clinical microbiology laboratory of the S.M.S. Medical College & Hospital, Jaipur from period of 1st January, 2007 to 13th November 2007 to evaluate the prevalence of anti HCV Antibody in symptomatic and asymptomatic individuals of 500 confirmed Liver disease patients. RAPID Test and ELISA TEST was done at clinical microbiology laboratory S.M.S. Medical College & Hospital, Jaipur. RESULT: Total no. of anti HCV antibody positive cases in our study were 4.2% in liver disease patients.All positive cases were above the age of 30 yrs.HCV positivity ratio among Male: Female was9.5:1(out of 311 males, 19 (6.10%) were positive and out of 189 females, 2 (1.05%) were positive for anti HCV antibodies in liver diseases patients).Highest prevalence of anti HCV antibodies was observed in the age group > 51 years (6.06%), followed by 5.43%, 2.58% in 31 – 40 years age groups and 41 – 50 years age groups respectively in liver diseases patients.Comparison of studies conducted by other researchers showed slight variations in prevalence of HCV infection.There is a scarcity of information on HCV prevalence particularly in developing countries like India, hence present study was conducted for early detection & prevention.