HEPATITIS C VIRUS SEROPREVALNCE IN RENAL DISEASE PATIENTS AT SMS HOSPITAL AND ALLIED HOSPITALS

DR. BHUPENDRA KUMAR MANDAWAT; DR. LEELA VYAS

Volume : VIII, Issue : VII, July - 2019

HEPATITIS C VIRUS SEROPREVALNCE IN RENAL DISEASE PATIENTS AT SMS HOSPITAL AND ALLIED HOSPITALS

Dr. Bhupendra Kumar Mandawat, Dr. Leela Vyas

Abstract :

To assess the Seroprevalence of Hepatitis C virus in Renal Disease patients at SMS Hospital and Allied Hospitals. Various Renal disorders like ARF, CRF,Renal Failure Case without dialysis, Renal Failure Case with Maintenance Dialysis, Following Renal Transplant and Other Renal Diseases(with abnormal renal function test) cause multi organ failure leading to death. Infection with hepatitis C virus is a common nosocomial occurrence among hemodialysis(HD) patients(13). It is considered a causeof end–stage liver disease and contributes to high mortality and morbidity among patients on maintenance dialysis and following renal transplant cases(12). BACKGROUND: Hepatitis C virus infection is highly prevalent among Various Renal disorders. The prevalence of HCV infection in HD patients varies markedly from country to country. The prevalence of HCV among dialysis patients in India is reported to range between 20 and 80%.(19) However, the prevalence of HCV infection in the western countries ranges between 4 and 23.3%.(21) OBJECTIVES:To find out the seroprevalence of anti HCV antibodies in various categories of Renal Disease patients from different OPDS, wards and ICUs of SMS Hospital and J.K. Loan, Mahila Chikitsalaya and Zanana Hospital Jaipur etc.This study is conducted to aid in early detection & treatment & its prevention of HCV Virus infection in renal disease patients. METHODOLOGY:The study is conducted in the clinical microbiology laboratory of the S.M.S. Medical College & Hospital, Jaipur from period of 1st January, 2007 to 13th November 2007 to evaluate the prevalence of anti HCV Antibody in symptomatic and asymptomatic individuals of 500 Renal disease patients. RAPID Test and ELISA TEST was done at clinical microbiology laboratory S.M.S. Medical College & Hospital, Jaipur. RESULT: Total no. of anti HCV antibody positive cases in our study were very low 0.6% in Renal disease patients. Out of 500 sample tested for various renal diseases 3 (0.6%) were positive for anti HCV antibodies.HCV seroprevalence was maximum in following case of renal transplant (7.69%), followed by 0.93% in renal failure cases with maintenance dialysis HCV seroprevalence was seen maximum in 21 – 30 year age group (5.26%), followed by 0.8% in 41 – 50 year age groups and 0.55% in > 51 years age groups. Out of 356 males sample tested–3 (0.8%) were positive for anti HCV antibodies and out of 144 females patients none were positive for anti HCV antibodies in 500 renal diseases patients.Comparison of studies conducted by other researchers showed slight variations in prevalence of HCV infection.There is a scarcity of information on HCV prevalence particularly in developing countries like India, hence present study was conducted for early detection & prevention in Renal disease patients