Hepato-cellular toxicity among the exposures to the diesel combustion nano-particles

Dr. D. R. Mahadeshwara Prasad; Shashank Srivasthav; Dr. Malini. S. S

Volume : VIII, Issue : II, February - 2019

Hepato-cellular toxicity among the exposures to the diesel combustion nano-particles

Dr. D. R. Mahadeshwara Prasad, Shashank Srivasthav, Dr. Malini. S. S

Abstract :

Toxic organic byproducts of diesel combustion nano–particles are widely spread in the current environment and in more concentration in the congested urban areas and in non ventilated workshops. The present study conducted to evaluate the toxic effect of these nano–particles on hepatic function and biomarkers of oxidative stress among the exposed individuals. Serum sample was analysed for the determination of serum glutamic–oxaloacetic transaminase (SGOT), serum glutamic–pyruvate transaminase (SGPT), total protein, and estimation of catalase (CAT), superoxide dismutase (SOD) and melanadehyde (MDA) among the control and exposed individuals. Our data showed a significant increase in SGOT, SGPT, total protein and albumin and also significant variation in oxidative stress parameters in serum among the cases exposed to diesel combustion nano–particles for more than 5years compared to the control population. These changes were more obvious in long term exposures of 5 and more years. Thus we could able to conclude that toxic organic byproducts of diesel combustion nano–particles affect adversely and alter biochemical markers in vital organ.