IMMUNOHISTOCHEMICAL EXPRESSIONS OF CK5 AND CK8/18 IN TRIPLE NEGATIVE BREAST CANCERS

Adeodata Lily Wibisono; Delyuzar; Betty

Volume : VII, Issue : IX, September - 2018

IMMUNOHISTOCHEMICAL EXPRESSIONS OF CK5 AND CK8/18 IN TRIPLE NEGATIVE BREAST CANCERS

Adeodata Lily Wibisono, Delyuzar, Betty

Abstract :

A cross–sectional study of 58 triple negative east cancer (TNBC) patients’ formalin–fixed paraffin–embedded tissue blocks was conducted to assess the immunohistochemical expressions of CK5 (basal cell marker) and CK8/18(luminal cell marker) as well as their association with various TNBC clinicopathological parameters, such as patients’ age, menopausal status, disease stage, tumor size, lymph node involvement, distant metastasis, histological type, grade, and mitosis.Statistical analyses were performed by using independent sample Student t, Pearson’s Chi square and Fisher’s exact test. Basal–like subtype identified by positive CK5 expression was observed in 43.1% of TNBC cases while negative CK8/18 expression was seen in 13.8% of cases. Both biomarkers expressions showed no significant association with observed clinicopathological parameters. However, CK5 was found to besignificantly associated with mitosis (p = 0,032).