INCIDENCE OF HYPOGLYCEMIA IN NEWBORN AT RISK AND FOLLOW-UP STUDY OF THEIR NEURODEVELOPMENT AT 3 AND 6 MONTHS AGE

Dr. Rajendra Meher; Dr. Sasmita Devi Agrawal; Dr. Shubhankar samal; Dr. Sidhant Swarup; Dr. Pankaj Garg; Dr. Hemant Agrawal

Volume : IX, Issue : II, February - 2020

INCIDENCE OF HYPOGLYCEMIA IN NEWBORN AT RISK AND FOLLOW-UP STUDY OF THEIR NEURODEVELOPMENT AT 3 AND 6 MONTHS AGE

Dr. Rajendra Meher, Dr. Sasmita Devi Agrawal, Dr. Shubhankar Samal, Dr. Sidhant Swarup, Dr. Pankaj Garg, Dr. Hemant Agrawal

Abstract :

Background: Glucose is an essential molecule that supplies energy for ain consumption. Neurons and glial cells in the ain are sensitive to hypoglycemia. Thus hypoglycemia may negatively affect neurological and developmental prognosis. Objective: This study aimed to investigate the incidence of hypoglycemia in newborn infants at risk & study their neurodevelopment at 3 and 6 months age. Methods: The observational study was conducted in babies born with risk factors for hypoglycemia like infant of diabetic mother (IGDM/IDM), LGA (birth weight >90th percentile), SGA (birth weight <10th percentile), late preterm (34–37 weeks). Babies with major congenital malformations ,with perinatal asphyxia, on formula or prelacteal feed and admitted in NICU for other reasons were excluded.The neurodevelopment of these babies (longitudinal study) was evaluated by the DASII scoring method at 3 and 6 months age. Results: Of the 142 newborn infants at risk ,there were 15 cases in IDM group (10.56), 32 cases in LGA group (22.53%), 39 cases in SGA group (27.46%), 56 cases in LPI group (39.44`%). The incidence of hypoglycemia in these four groups were 4 (26.67%), 7 (21.87%), 10(25.64%), 17 (30.35%) respectively. Infants at risk having episodes of neonatal hypoglycemia have poor neurodevelopmental outcome (assessed by DASII scoring method) . Conclusion: The incidence of hypoglycemia(26.76%) was found to be maximum among LPI group ,followed by IDM group, than SGA group and minimum among LGA group. Long and repeated neonatal hypoglycemia caused poor adaptability.