INDUCIBLE CLINDAMYCIN RESISTANCE IN STAPHYLOCOCCAL ISOLATES FROM OCULAR SAMPLES

Dr. Pallati Alekhya; Dr. C.Aruna Sunder; Dr. Prathibha

Volume : VIII, Issue : I, January - 2019

INDUCIBLE CLINDAMYCIN RESISTANCE IN STAPHYLOCOCCAL ISOLATES FROM OCULAR SAMPLES

Dr. Pallati Alekhya, Dr. C. Aruna Sunder, Dr. Prathibha

Abstract :

Clinical failure of clindamycin therapy has been reported due to multiple mechanisms that confer resistance to macrolide, lincosamide and streptogramin antibiotics. This study was undertaken to detect the presence of inducible clindamycin resistance among clinical isolates of Staphylococci from ocular samples in a tertiary care eye hospital. The detection of inducible clindamycin resistance was performed by D–test using erythromycin and clindamycin discs as per CDC guidelines. Among 217 ocular samples 100 isolates of Staphylococci were studied, 8 (8%) showed inducible clindamycin resistance and belonged to the iMLSB phenotype. Among the iMLSB phenotypes, 1 isolates was methicillin–resistant Staphylococcus aureus, 1 was methicillin–sensitive Staphylococcus aureus and 6 were coagulase negative Staphylococci. The test for inducible resistance to clindamycin should be included in the routine antibiotic susceptibility testing of Staphylococci for ocular samples, as it will help in guiding the therapy.