Interleukin 10 analogue as a promising alternative, in the management of Preterm premature rupture of membranes - A Comparative study.

Dr. Kshama Kedar; Dr. Pariksha Singh; Dr. Monika Akare

Volume : VII, Issue : I, January - 2018

Interleukin 10 analogue as a promising alternative, in the management of Preterm premature rupture of membranes - A Comparative study.

Dr. Kshama Kedar, Dr. Pariksha Singh, Dr. Monika Akare

Abstract :

Preterm Premature rupture of memanes (PPROM) is one of the most important dilemmas in current obstetric practice. IL10 is a natural immunoregulatory cytokine required for preventing preterm labour induced by inflammatory cytokine. In this study, pregnant women in the study group were given Amnioseal (interleukin 10 analogue), tocolytic, antibiotics and corticosteroids and control group received tocolytic, antibiotics and corticosteroids. Significant increase in the period of latency, period for which patient remains undelivered, was seen in the study group (28.36±8.76 days) than in the control group (10.28±5.13 days). The perinatal morbidity and mortality was significantly less in patients receiving Amnioseal, owing to increased gestational age and the favorable milieu externa of amniotic fluid which enables better survival prospects for baby as well as higher birth weight. Interleukin 10 analogue is a promising alternative to conventional therapeutic regimen for management of PPROM.