LONG TERM FOLLOW-UP IN PEOPLE WITH PATENT FORAMEN OVALE (PFO)

N. Alessandri; M. Raponi; A. Stipo; F. Tersigni; C. Alessandri; . A. Khan

Volume : VII, Issue : IV, April - 2018

LONG TERM FOLLOW-UP IN PEOPLE WITH PATENT FORAMEN OVALE (PFO)

N. Alessandri, M. Raponi, A. Stipo, F. Tersigni, C. Alessandri, . A. Khan

Abstract :

OBJECTIVE 8 years follow–up (6.8 ± 2.2 years) of subjects with PFO. The evaluation of the incidence of cryptogenetic Stroke/TIA and/or migraine and/or platypnea–orthodoxy in subjects with PFO with and without closure.

METHODS:74 subjects were studied (17 M, 57 F), ), all originating from Latina and surrounding areas, with an average age of 50.3 ± 11.2 years; 56 patient were subjected to percutaneous closure for TIA/cryptogenetic stroke between the years 2008 and 2016. All patients under the same control protocol during the mean follow–up of 6.8 ± 2.2 years;

RESULTS: there was no evidence of cereovascular recurrences in patients who had undergoing closure and in patients with medical prophylaxis. In 30/74 patients with migraine (with or without aurea), 13 sujects remainedsymptomatic after closure: 8 patients reported migraine with platypnea–orthodoxy, 2 patients symptoms free after closure. Two patients died > 12 months after the procedure from non–cardiovascular disease.

CONCLUSION:Long–term follow–up, in a "selected" population for specific delivery from other medical centers, highlighted a high reduction (p< 0.01) in events associated with PFO with its closure. In the group undergoing percutaneous closure of the PFO, a significant reduction (p <0.001) of the incidence of cereovascular events (stroke / TIA) and (p <0.001) was observed in the reduction of other associations (migraine and / or platypse–orthodoxy ).