Mortality factors for severe malaria in adults in the intensive care unit of Tambohobe-Fianarantsoa Teaching Hospital.

Rasamoelina Ndrantoniaina; Andrianimaro FM; Andriamamonjisoa J; Rakotomavo F; Razafimahefa SH; Rakotoarivelo RA; Raveloson NE

Volume : VII, Issue : II, February - 2018

Mortality factors for severe malaria in adults in the intensive care unit of Tambohobe-Fianarantsoa Teaching Hospital.

Rasamoelina Ndrantoniaina, Andrianimaro Fm, Andriamamonjisoa J, Rakotomavo F, Razafimahefa Sh, Rakotoarivelo Ra, Raveloson Ne

Abstract :

Objective: To determine predictive factors for severe adult malaria mortality in Teaching Hospital of Fianarantsoa.

Patients and methods: This is a descriptive retrospective study carried out over a period of 36 months, dealing with cases of severe adult malaria, treated at the Medical–Surgical Intensive Care Unit of the Tambohobe–Fianarantsoa Teaching Hospital. The patients were divided into two groups: a group of survivors and a group of deceased persons. A comparative study was carried out by analyzing: the age of the patients, the gender, the time of care in intensive care, the sector of activity, the origin, the clinical signs of gravity, the biological signs of gravity, the reference , the antimalarial used.

Results : We selected 123 patients. Age greater than 45 years was associated with mortality (p = 0.011). The mortality of severe malaria was predominantly male (n = 34/47, 72.3%) (p = 0.645). The delay in treatment beyond 24 hours was significantly related to mortality (p <0.0001) and patient self–reference (p <0.0001). Respiratory failure was found in the 8 patients (6.5%) with a mortality rate of 87.5% (p = 0.003).

Conclusion: Predictors of severe malaria mortality were: age, delayed management, patient self–referral, and respiratory failure.