PARIPEX - Indian Journal of Research

Dr. Tasneem lilamwala; ALLURI KRISHNAM RAJU

Volume : VIII, Issue : V, May - 2019

PERIOPERATIVE IMAGE-GUIDED HDR INTERSTITIAL BRACHYTHERAPY IN EXTREMITY SOFT TISSUE SARCOMAS-A SINGLE TERTIARY CANCER CENTRE STUDY-SOUTH INDIAN DATA

Dr. Tasneem Lilamwala, Alluri Krishnam Raju

Abstract :

OBJECTIVE/AIM: To report our oncological outcomes and the late radiation induced toxicities with image guided HDR achytherapy in extremity soft tissue sarcomas. METHODS & MATERIALS: From August 2007 to April 2015, thirty one cases were retrieved and 20 cases were analyzed (14 primary and 6 recurrent).The follow up period was between 13 months and 93 months. The inclusion criteria for HDR achytherapy were as follows:1.high grade tumor 2. low grade tumor >10cms 3.recurrent tumor 4.positive /close margins.All patients underwent image guided (CT–based) planning and were delivered 3–3.5 Gy/fraction *6/7, twice daily. Three weeks later, patient received EBRT(45–54Gy).Median follow–up was 48 months. RESULTS: There were 2 cases of local failure within the radiation field. The local control rate was 90%.Among the late complications, 10 %( 2/20 patients) developed RTOG Grade II restricted joint movements. One patient developed Grade IV radiation dermatitis (non healing ulcer).Fifty percentage of patients developed Grade I myalgia & 15% (3/20) had Grade II myalgia(NCI–CTCAE v4.0) CONCLUSION: Image guided perioperative HDR achytherapy provides reasonable local control rates in extremity soft tissue sarcoma with acceptable complications even in recurrent cases