Periventricular nodular heterotopia associated with polymicrogyri and partial agenesis of corpus callosum

Dr. Sanjay Pasoria; Dr. Harshvardhan Singh Rathore; Dr. Thahir V.U.; Dr. Tulsi Manek

Volume : VIII, Issue : VII, July - 2019

Periventricular nodular heterotopia associated with polymicrogyri and partial agenesis of corpus callosum

Dr. Sanjay Pasoria, Dr. Harshvardhan Singh Rathore, Dr. Thahir V. U. , Dr. Tulsi Manek

Abstract :

Periventricular nodular heterotopia (PNH)is the most common form of grey matter heterotopia which is characterized by nodules of grey matter located along the lateral ventricles . It is mostly bilateral and occurs due to improper immigration of neurons during early development of fetal ain. The patient most commonly presents with epilepsy and sometimes with developmental delay. Two different types of periventricular nodular heterotopia have been described in literature, namely bilateral and unilateral PNH. Bilateral PNH follows an X–linked dominant inheritance pattern. Most affected individuals are females. There are only a few reports of affected males, since X–linked inheritance means that development of most of the male emyos fails to progress. We report a case of 33 year old male presented to us with history of headache , seizure and delayed milestones since 20 years