Polymorphism of Red Blood Cell in Peripheral blood smear of Thalassemia affected person.

Sapkal H.P.; Mahakalkar A.L.; K.M. Kulkarni

Volume : VIII, Issue : IV, April - 2019

Polymorphism of Red Blood Cell in Peripheral blood smear of Thalassemia affected person.

Sapkal H. P. , Mahakalkar A. L. , K. M. Kulkarni

Abstract :

The thalassemias are classified according to which chain of the hemoglobin molecule is affected. In a thalassemias, production of the á globin chain is affected, while in â thalassemia production of the a globin chain is affected. Thalassemia produces a deficiency of α or β globin, unlike sickle–cell disease which produces a specific mutant form of β globin. β globin chains are encoded by a single gene on chromosome 11; α globin chains are encoded by two closely linked genes on chromosome 16. Thus in a normal person with two copies of each chromosome, there are two loci encoding the β chain, and four loci encoding the α chain thus it affected the morphology of red blood cell i.e. erythrocytes