PREDICTION OF OUTCOME IN PATIENTS WITH SEPSIS USING C-REACTIVE PROTEIN (CRP) AND SIMPLIFIED ACUTE PHYSIOLOGY SCORING SYSTEM 3 (SAPS3)

Mohammad Shareef. V; Vijaysagar Reddy Bonapelli; Prakruthi J

Volume : VIII, Issue : III, March - 2019

PREDICTION OF OUTCOME IN PATIENTS WITH SEPSIS USING C-REACTIVE PROTEIN (CRP) AND SIMPLIFIED ACUTE PHYSIOLOGY SCORING SYSTEM 3 (SAPS3)

Mohammad Shareef. V, Vijaysagar Reddy Bonapelli, Prakruthi J

Abstract :

Background: Sepsis is associated with high mortality and morbidity if not recognised early. Hence scoring systems are essential to guide us regarding the initiation of treatment. Sepsis can progress to a multitude of complications and assessing the mortality is difficult without the scores. Objectives: 1. To find whether there is a correlation between admission CRP level and outcome in patients with sepsis. 2. To find the correlation between SAPS3 and outcome in patients with sepsis. 3. To find a correlation by combining admission CRP level and SAPS3 in predicting mortality in sepsis patients. Methods: This prospective observational study was conducted in Yenepoya Medical College from Jan 2015 to Jan 2016. 50 patients admitted to the ICU who fulfil the inclusion criteria were enrolled in the study. Serum CRP and variables to calculate the SAPS3 score were collected within 1 hour of admission. The values of CRP levels and SAPS3 score were compared, in relation to the severity and outcome of the disease. Results: Out of 50 patients, 26 patients were male and 24 patients were female. Majority of the patients were with age group of 40–60 yrs. Mean CRP levels in patients were 67 mg/dl. Higher the CRP, prognosis was bad. CRP had sensitivity of 82% and specificity of 0 % in predicting mortality in patients with sepsis and was not statistically significant (p =.115). Mean SAPS3 score in patients were 45.3. Majority of patients expired when SAPS3 score of > 40. We observed SAPS3 score had sensitivity of 100% and specificity of 84% in predicting mortality in patients with sepsis, which was statistically significant (p .026). When we take both CRP level and SAPS3 score, we observed no correlation in predicting the mortality (statistically not significant). Conclusion: These results suggest that SAPS3 score alone is better for predicting the mortality in sepsis, than using CRP alone or in combination.