Preliminary investigation into the effect of amphotericin B with Fluconazole in Cryptococcal meningitis patient with amphotericin B as control.

Dr. Hemant Gupta; Dr. Utina Kichu; Dr. Shalini Akulwar; Dr Deepak Gholape

Volume : VIII, Issue : I, January - 2019

Preliminary investigation into the effect of amphotericin B with Fluconazole in Cryptococcal meningitis patient with amphotericin B as control.

Dr. Hemant Gupta, Dr. Utina Kichu, Dr. Shalini Akulwar, Dr Deepak Gholape

Abstract :

BACKGROUND: HIV infection is a global pandemic with cases reported from virtually every country. According to UNAIDS, 36.7 million people around the world are currently suffering from HIV/AIDS. 2.1 million children are living with HIV.Globally , it is estimated that approximately 957,900 cases of cryptococcal meningoencephalitis occur each year, resulting in more than 600,000 deaths. MATERIALS AND METHODS:A randomized control study comprising of 84 cases in the age group of >12 years old admitted in tertiary care centre with HIV infection having cryptococcal meningitis diagnosed by CSF study were randomised into 2 groups and were given inj Amphotericin B and Amphotericin B plus fluconazole and were compared. RESULTS: Study shows that amphotericine B + fluconazole was the most rapidly fungicidal combination in CSF, compared with amphotericine B alone.