PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA ISOLATES IN A TERTIARY CARE HOSPITAL

Dr. R. Nepoleon; Dr. Daya Pauline S.

Volume : VIII, Issue : V, May - 2019

PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA ISOLATES IN A TERTIARY CARE HOSPITAL

Dr. R. Nepoleon, Dr. Daya Pauline S.

Abstract :

Introduction– Resistance to first line antibiotics creates a situation similar to pre–antibiotic era, for treating any infection using high level antibiotics. Information about the prevailing antibiotic resistance among common pathogens is useful in making an appropriate choice of empiric therapy. Klebsiella is an important pathogen concerning humans causing increased morbidity and mortality. Among Klebsiella, K. pneumoniae is considered as the predominant organism causing multidrug resistance. Aim– To find out the prevalence of Klebsiella isolates and their antibiotic susceptibility pattern among various clinical isolates. Methodology – Study design and setting: A cross sectional study conducted in the department of Microbiology, Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari District. Study period: One year (January 2018 – December 2018). Antibiotic susceptibility testing of all isolates was performed by Kirby–Bauer’s disc diffusion method and interpretation of the results was done. Results– During this one–year study period, a total of 1090 cultures were positive for growth, of which 133 (12.2%) were found to be Klebsiella. Among the Klebsiella isolates, 56 were ESBL positive. Conclusion– The findings of this study emphasized the need for constant monitoring of susceptibility of specific pathogens in different populations to commonly used antimicrobial agents. These data may be used to determine trends in antimicrobial susceptibilities, to formulate local antibiotic policies in order to assist clinicians in the rational choice of antibiotic therapy, thereby preventing misuse or overuse of antibiotics