PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING UROPATHOGENS AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERN IN PATIENTS VISITING A TERTIARY CARE HOSPITAL

Shweta Singh; Ranjan Kumar Shrivastava; Babita Kumari; Spriha Smriti; Pratulya Nandan; Shiv Akshat

Volume : VIII, Issue : II, February - 2019

PREVALENCE OF EXTENDED SPECTRUM BETA LACTAMASE PRODUCING UROPATHOGENS AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERN IN PATIENTS VISITING A TERTIARY CARE HOSPITAL

Shweta Singh, Ranjan Kumar Shrivastava, Babita Kumari, Spriha Smriti, Pratulya Nandan, Shiv Akshat

Abstract :

Introduction : UTI is an important cause of morbidity and mortality in both developing and developed countries of the world. Globally, there is a changing trend in the antibiotic susceptibility pattern of the Gram– negative uropathogens , which are the most important causative organisms causing UTI . This is due to production of ESBL , which causes resistance to most beta– lactam antibiotics including third– generation cephalosporins, quinolones and aminoglycosides.Aims & objective : This study was done to find the prevalence of ESBL isolates and to study the antibiotic susceptibility patterns in uropathogens. Materials and methods : This study was conducted in the Department of Microbiology , PMCH ,Patna, from April 2018 to August 2018. All isolates were identified upto the species level . Results were interpreted according to CLSI 2018 guidelines. Results : Out of a total of 4073 urine samples collected from male and female patients , 578 of them showed growth. Escherichia coli was reported to be maximum (55.3%) , followed by Klebsiella spp. , Pseudomonas aeruginosa , Citrobacter spp. , Enterobacter spp. and Proteus spp..ESBL production was mostly prevalent in Escherichia coli followed by Klebsiella spp .Discussion & Conclusion: This study showed a high rate of ESBL production.