PARIPEX - Indian Journal of Research

Mounika Guntaka; Ashish Kumar Jangir; Babulreddy Hanmayyagari; Venkata Satyanaraya; Mengade Manoj Gopinath; Griddaluru Veera Chanukya

Volume : VIII, Issue : III, March - 2019

Prevalence of latent autoimmune diabetes in adults: Experience from a single centre in south India.

Mounika Guntaka, Ashish Kumar Jangir, Babulreddy Hanmayyagari, Venkata Satyanaraya, Mengade Manoj Gopinath, Griddaluru Veera Chanukya

Abstract :

Latent autoimmune diabetes in adults (LADA) is a heterogeneous clinical entity where patients are usually diagnosed at later age and are mostly misdiagnosed as type 2 Diabetes Mellitus (T2 DM). Though they respond to oral hypoglycemic agents (OHA’S) initially, but require insulin dependent therapy more rapidly than with type 2 DM patients. Like Type 1 Diabetes mellitus (T1DM) this group of patients also express circulating beta (β) cell autoantibodies. Methods: This is a cross sectional study to estimate the prevalence of LADA in south Indian population conducted from 2 centre’s in Hyderabad. Sixty four patients who were newly diagnosed with diabetes mellitus (aged between 15– 55 years) were recruited in to the study after careful exclusion. All subjects were screened for GAD, IAA, IA– 2 antibodies using ELISA kits provided by Aesku Diagnostics (Oakland, CA). Results: GAD–65 auto antibodies were positive in 23.4 % (16) patients, IAA auto antibodies were positive in 4.7% (3) patients, IA–2 auto antibodies were positive in 3.1%( 2) patients. Most of these subjects are younger with normal BMI and had low C–peptide levels. Conclusion: The prevalence of LADA is 32% in this study, indicates this form of diabetes is not uncommon. So it is imperative to investigate for this form of diabetes for specific treatment from the outset of the disease, thereby it benefits the patient and the society