PROGNOSIS OF EWING SARCOMA BY QUANTITATIVE HISTOPATHOLOGICAL METHODS

Roxana Filip; Florin Filip; Laurian Lucian Francu

Volume : VII, Issue : IX, September - 2018

PROGNOSIS OF EWING SARCOMA BY QUANTITATIVE HISTOPATHOLOGICAL METHODS

Roxana Filip, Florin Filip, Laurian Lucian Francu

Abstract :

Ewing‘s sarcoma is an increased incidence tumor, with radiological polymorph appearance that mimics a multitude of bone diseases.It has an incompletely elucidated origin, monotone microscopic image, but high aggressiveness.Exceptional sensitivity to radiotherapy requires precise diagnosis as early as possible. These peculiarities suggested the evaluation of stereological microscopic structure and its proliferative activity.For this purpose we had studied anatomopathologicaly 42 bone tumors from children with ages between 3–18 years from Iasi hospitals.Quantitative measurements were performed using the interactive digital program PRODIT 5.2. The quantified stereological parameters objectifies the microscopic appearance of Ewing‘s sarcoma, but can not be used to assess the prognosis and the tumor progression. Quantification of the proliferative activity can be used to assess the prognosis only in case of sure diagnosis, the values above 2/10 hpf indicating increased risk.