REGULATORY ROLE OF THYROXINE ON GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY IN INDIAN TOAD

SUREKHA NAYAK; BIBHUPADA MAHAPATRA; GITANJALI MISHRA

Volume : VIII, Issue : V, May - 2019

REGULATORY ROLE OF THYROXINE ON GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY IN INDIAN TOAD

Surekha Nayak, Bibhupada Mahapatra, Gitanjali Mishra

Abstract :

A review of the hormonal control of G6PDH activity reveals that much less work has been done on the effect of thyroxine on the above enzyme. This is probably because of, equivocal consideration of thyroxine as a metabolic hormone for its adaptive role in all the metabolic processes and its primary involvement in glycogenolysis and gluconeogenesis. Much less attention has, so far been paid to the enzymes of HMP–shunt, despite the fact that this pathway also provides substrates such as fructose–6–phosphate and glyceraldehydes–3–phosphate to gluconeogenesis. Precisely why, the present work has been designed to study the effect of the hormone thyroxine in vivo, on the activity of the enzyme G6PDH in liver of Indian toad, Bufo melanostictus. Thyroxine caused significant inhibition of G6PDH activity in vivo in liver of toads at two different dose levels