Volume : VIII, Issue : VIII, August - 2019
ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CARCINOMA
Dr Monika Aggarwal, Dr Vs Srinivas, Dr Vs Nijhawan, Dr Vibha Dutta
Abstract :
Colorectal carcinoma has etiopathogenesis related to both environmental and genetic factors. Epidermal growth factor receptor (EGFR) and its downstream signaling pathways regulate the key cellular events that drive the progression of many neoplasms. Thirty cases of colorectal carcinoma (CRC) were studied using H&E stain for morphology, grade and stage and further IHC was done for EGFR mutations. Our study found that the poorly differentiated adenocarcinoma and moderately differentiated adenocarcinoma showed stronger EGFR staining as compared to well differentiated adenocarcinoma. So, higher the grade of tumor, stronger is the EGFR positivity. EGFR expression detection by IHC is a sensitive and specific marker in CRC. The findings of positivity will help in guiding the therapy and better survival in patients of CRC.
Keywords :
EGFR (Epidermal Growth factor Receptor) IHC (Immunohistochemistry) H&E (Hematoxylin and Eosin stain) CRC (Colorectal carcinoma)
Article:
Download PDF
DOI : https://www.doi.org/10.36106/paripex
Cite This Article:
ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CARCINOMA, Dr Monika Aggarwal, Dr VS Srinivas, Dr VS Nijhawan, Dr Vibha Dutta PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-8 | Issue-8 | August-2019
Number of Downloads : 115
References :
ROLE OF EPIDERMAL GROWTH FACTOR RECEPTOR IN COLORECTAL CARCINOMA, Dr Monika Aggarwal, Dr VS Srinivas, Dr VS Nijhawan, Dr Vibha Dutta PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-8 | Issue-8 | August-2019