Role of FNAC in differential diagnosis of HIV lymphadenopathy and correlation with CD4 count

Sunanda Nayak; Gitimadhuri Dutta; Asaranti Kar; Kailash Chandra Agarwal

Volume : VII, Issue : VII, July - 2018

Role of FNAC in differential diagnosis of HIV lymphadenopathy and correlation with CD4 count

Sunanda Nayak, Gitimadhuri Dutta, Asaranti Kar, Kailash Chandra Agarwal

Abstract :

Lymphadenopathy is one of the earliest manifestation of HIV infection.It may be due to presence and effects of HIV,opportunistic infections,lymphoid malignancy etc.FNAC is a primary investigative procedure in the assessment of cause of lymphadenopathy.This study is performed to evaluate the role of FNAC in the differential diagnosis of HIV lymphadenopathy.

Materials and Methods :–

This is a retrospective study consists of FNAC samples obtained from HIV patients having lymphadenopathy attending Cytology section of Department of Pathology,VIMSAR, Burla for a period of 2 years from April 2016 to March 2018.Smears were stained with Diff Quick,H&E,Z–N stain,India ink and CD4 correlation was done in each case.

Results:–

Total 56 patients included in our study group among which 76.78% were male and rest were female.Cervical lymphadenopathy was the most common lesion (53.57%).Tubercular lymphadenitis was identified as the most common cause of lymphadenopathy in the present study.CD4 count in TB lymphadenitis ranged from 90–902/µl.with a mean CD$ count 440 /microlit.CD4 count in Cryptoccoccal infection was <50/µl.

Conclusion:–

The present study revealed the utility of lymphnode cytology in the diagnosis and segregation of lymphadenpathy in HIV positive patients.It is simple,cost effective and valuable tool in the clinical management of AIDS patients