Role of Oral Pentosan Polysulfate in Treatment of Double J Stent Related Lower Urinary Symptoms - A Pilot Study.

Dr. Sameer Vyas; Dr.Nachiket Vyas; Dr.Vinay Tomar; Dr. S.S Yadav; Dr.Shivam Priyadarshi; Dr.Neeraj Agarwal

Volume : VII, Issue : VII, July - 2018

Role of Oral Pentosan Polysulfate in Treatment of Double J Stent Related Lower Urinary Symptoms - A Pilot Study.

Dr. Sameer Vyas, Dr. Nachiket Vyas, Dr. Vinay Tomar, Dr. S. S Yadav, Dr. Shivam Priyadarshi, Dr. Neeraj Agarwal

Abstract :

Introduction – Double J stents affect the quality of life in up to 80% of cases,in this study we intended to evaluate the role of Pentosan Polysulfate (PPS) – an analogue of urinary bladder glycosaminoglycans in relieving Double J stent related symptoms.

Methods –82 patients were randomised into 4 groups, group A (N=21) received PPS 100 mg once daily for 2 weeks, group B (N=20)–PPS 100 mg thrice dailyfor 2 weeks, group C (N=19) –PPS 100 mg thrice daily for 1^st week then placebo for 2^nd week &group D (N=22) – placebo. Treatment was started at 1^st week post surgery till removal of stent at 3^rd week. All patients were evaluated with ureteral stent symptom questionnaire. Statistical tests were applied and level of significance was set at p value<0.05.

Results – Urinary symptoms, body pain and general health scores were significantly lower with PPS both after 1^stand 2^nd week of treatment as compared to placebo (p value < 0.05). Improvement in work performance and additional health problem scores was not significant and sexual health scores did not improve on PPS, 100 mg thrice daily dose had lower scores after 1^st week of treatment in comparison to once daily dose but after 2 weeksthe difference was not significant.

Conclusion: Pentosan Polysulfate (PPS) is a safe, well tolerated and effective drug in relieving DJ stent related symptoms. It can be started at 100 mg thrice daily dose and can be reduced to once dailydose after 1 week.