SERUM MALONDIALDEHYDE LEVELS IN CHILDREN WITH NEPHROTIC SYNDROME IN FULL DOSE CORTICOSTEROID AND FINISHED THERAPY

Riska Habriel Ruslie; Oke Rina Ramayani; Yazid Dimyati

Volume : VII, Issue : III, March - 2018

SERUM MALONDIALDEHYDE LEVELS IN CHILDREN WITH NEPHROTIC SYNDROME IN FULL DOSE CORTICOSTEROID AND FINISHED THERAPY

Riska Habriel Ruslie, Oke Rina Ramayani, Yazid Dimyati

Abstract :

A cross–sectional study of 50 nephrotic syndrome (NS) patients that were admitted to Pediatric Nephrology Department of Adam Malik General Hospital, Medan, Indonesia was conducted to determine the difference of Malondialdehyde (MDA) levels in NS patients who were receiving full–dose corticosteroid therapy and finished therapy. Diagnosis criteria for NS are massive proteinuria (>40mg/ m²/ hour or urine albumine creatinine ratio (UACR) >2 mg/g or dipstick ≥2+), hypoalbuminemia ≤ 2.5 g/dL, generalized edema, and may accompanied by hypercholesterolemia.

MDA levels were significantly higher in NS patients who were receiving full dose corticosteroid therapy than those who finished therapy. Furthermore, there was a significant negative correlation between albumin and MDA levels, and significant positive correlations between UACR and total cholesterol levels with MDA levels.