SIGNIFICANCE OF HISTOLOGICAL SUBCLINICAL CHORIOAMNIONITIS (HCA) IN SPONTANEOUS PRETERM LABOUR

Kanjoor Deepthi Damodaran Nair; Lola Ramachandran; Lincy Joseph

Volume : VII, Issue : II, February - 2018

SIGNIFICANCE OF HISTOLOGICAL SUBCLINICAL CHORIOAMNIONITIS (HCA) IN SPONTANEOUS PRETERM LABOUR

Kanjoor Deepthi Damodaran Nair, Lola Ramachandran, Lincy Joseph

Abstract :

OBJECTIVE: To look for evidence of HCA in spontaneous preterm labour by histopathological examination of the placenta and correlate early neonatal mortality with severity to HCA.

METHODOLOGY:The study consists of all women who are admitted with spontaneous preterm labour pain and after delivery placental examination was done.

RESULTS:60 cases were studied,33 were late preterm (55%),15 were moderate(25%),8 very preterm(13%)and 4 extreme preterm(7%).Percentage of HCA in each group was 15,80,75&100 respectively.Mean gestational age and mean birth weight of HCA group(n=27)was 31.40±1.13 and 1706.40± 227.58 and without HCA(n=33)was 34.51±0.54 and 2245.90 ±162.47 respectively.The maternal total leucocyte count was significantly high in HCA group.maternal CRP was raised in 26 patients of which 22 had HCA.Neonatal mortality was 3 amongst 60, 3 of the babies had HCA.

CONCLUSION: In our study,we found that HCA is significantly correlated with lower gestational age,lower birth weight,higher maternal total leucocyte count,higher maternal CRP,thus suggesting that maternal inflammation could be one of the causes of spontaneous preterm birth.