STUDY BIOCHEMICAL PARAMETER LDH IN OVARIAN TUMORS BEFORE AND AFTER CHEMOTHERAPY

Dr.G.Veena Murty; Dr.Prem Kumar; Dr. G. Rajeswari

Volume : VIII, Issue : IX, September - 2019

STUDY BIOCHEMICAL PARAMETER LDH IN OVARIAN TUMORS BEFORE AND AFTER CHEMOTHERAPY

Dr. G. Veena Murty, Dr. Prem Kumar, Dr. G. Rajeswari

Abstract :

Serum LDH elevations occur in a variety of clinical conditions including of MI, hemolysis and disorders of the liver, kidneys, lung and muscle. A systematic review of Literature concluded that serum LDH is relevant in the diagnosis of MI, hemolytic anemia, ovarian dysgerminoma and testicular germ cell tumor. Although not that relavent for epithelial ovarian cancer, LDH is considered important in the follow up of dysgerminoma for assessing response to therapy and prognostification of disease. The current study designied with an aim To explore the changes in LDH levels of malignant and benign ovarian tumours pre therapy and post therapy.To explore the differences in the LDH levels between healthy individuals and patients with ovarian tumours.To study the Correlation between CA125 and LDH. To study the Correlation between CA125 LDH. A study was conducted on 40 patients suffering from ovarian tumors (Benign and Malignant) who had reported to Rangaraya Medical College hospital, Kakinada. The mean duration of symptoms was 12.6 ± 20.89 weeks (range 0.4– 104 weeks) and the median was 6.5 weeks in our cohort of patients. The mean duration of symptoms for benign (n=11) tumors was 23.1 ± 33.1 weeks whereas for malignant (n=29) tumors the duration of symptoms was 8.62 ± 12.50 weeks. all patients with ovarian tumours (both malignant & benign) had a pretreatment mean ± SD value of CA125 was 767 ±1069 U/ml which reduced to a mean± SD value of 46.28 ± 41.28 U/ml post treatment (p< 0.0004). A significant change was found in the levels of LDH (Pretreatment value of 479±320.6 U/L and post treatment levels of 182.8±107U/L) (P<0.0001). When compared to healthy controls (mean CA–125:15.48 (range:5.7–22) & mean LDH:182.8 (range:140–300) [table–7], ovarian tumour patients had a higher CA–125 & LDH levels(mean CA–125: 767 & mean LDH:479.36). We also tried to see the correlation between CA–125 and LDH both in benign and malignant ovarian tumours. A positive correlation was found between CA125 levels and LDH in malignant ovarian tumours. In benign tumours, a positive correlation was found between CA125 and LDH. a negative correlation was observed between CA–125 and cholesterol levels.