STUDY OF DUAL IN VITRO ACTIVITY OF COLISTIN & MEROPENEM AGAINST MULTIDRUG RESISTANT GNB

DR. KETAKI VYANKATESH KULKARNI; DR. SANDHYA S. KULKARNI

Volume : VII, Issue : IV, April - 2018

STUDY OF DUAL IN VITRO ACTIVITY OF COLISTIN & MEROPENEM AGAINST MULTIDRUG RESISTANT GNB

Dr. Ketaki Vyankatesh Kulkarni, Dr. Sandhya S. Kulkarni

Abstract :

Background: Bacterial resistance towards antibiotics is a clinical threat because it increases the problem of infectious disease. Currently colistin is increasingly being used against multidrug resistant gram negative bacteria which include Pseudomonas aeruginosa,,Acinetobacterbaumanii, Escherichia coli, Klebsiellapneumoniae& Salmonella enterica. [1]. Combination antibiotic therapy is frequently used to treat severe gram negative infections though controversial &debatable.Methods: Total 200 MDR GNB isolates were included in the study which were further tested for their susceptibility to Colistin&Meropenem by Kirby Bauer Disc Diffusion Test. Results: Of 200 MDR GNB isolates, 69(34.5%) isolates showed resistance to Colistin.Out of 69 Colistin resistant isolates, 55(79.71 %) were resistant to Meropenem as well. Conclusion: As multidrug resistance is emerging rapidly,measures are necessary to restrict indiscriminate use of antimicrobials against common infections & adherence to the hospital antibiotic policy, which will further limit dissemination of bacteria that accumulate resistance to both colistin&carbapenems&/or to multiple antibiotics.