STUDY OF ETIOLOGICAL PROFILE OF PANCYTOPENIA IN A TERTIARY CARE HOSPITAL IN NORTHERN INDIA

DR.SHAHBAZ KHAN; Dr.VINEY SAMBYAL

Volume : VIII, Issue : IV, April - 2019

STUDY OF ETIOLOGICAL PROFILE OF PANCYTOPENIA IN A TERTIARY CARE HOSPITAL IN NORTHERN INDIA

Dr. Shahbaz Khan, Dr. Viney Sambyal

Abstract :

Background: Pancytopenia is defined as the simultaneous presence of anemia, leukopenia, and thrombocytopenia. The present study was undertaken to explore various causes and clinical manifestations of pancytopenia and to correlate them with severity of pancytopenia in adult patients in a tertiary care hospital of Jammu. The causes of pancytopenia are diverse. The spectrum of different etiologies leading to pancytopenia varies globally, as well as within different geographical regions of the same country like India. Aims and objectives: To evaluate various causes of pancytopenia in patients admitted to a tertiary care hospital of Jammu. Material and Methods: A total of 280 patients of pancytopenia over a period of 12 months were enrolled. Clinical history, relevant physical examination and primary haematological investigations followed by bone marrow aspiration and trephine biopsy were done in all patients. Results: Among all the 280 cases with pancytopenia, the most common cause was megaloblastic anemia (169/280, 60.4%) followed by acute Leukemia (38/280, 13.6%) and multilple myeloma (25/280, 8.9%).Other uncommon causes include myelodysplastic syndrome (2.5%) and infections (like Tuberculosis 1.07 %). One sixty eight were males with one hundred twelve females in 280 studied patients with a mean age of 43.81 years. Conclusion: Thus, a comprehensive clinical, and hematological study of patients with pancytopenia will usually help in identifying the underlying cause. The early detection of the underlying conditions would also help to enhance the prognosis of patients with pancytopenia.