STUDY OF PATTERNS OF BRONCHIAL HYPERRESPONSIVENESS IN RELATIVES OF PATIENTS OF BRONCHIAL ASTHMA

Dr Vevek Rana; Dr Nidhi Anand; Dr Hema Malik

Volume : VII, Issue : XII, December - 2018

STUDY OF PATTERNS OF BRONCHIAL HYPERRESPONSIVENESS IN RELATIVES OF PATIENTS OF BRONCHIAL ASTHMA

Dr Vevek Rana, Dr Nidhi Anand, Dr Hema Malik

Abstract :

Objectives: To determine the patterns of onchial hyperresponsiveness in relatives of patients of onchial asthma and to observe its relationship with atopic state and exercise.

Methods: Group A ( control) had 25 subjects who were normal with no family history of Bronchial Asthma. Group B had 50 subjects with first degree relative having Bronchial Asthma. They were further subjected to intradermal skin testing with six common commercially prepared antigens, histamine challenge test and exercise testing.

Results: On histamine challenge 15 out of 50 subjects reacted with a fall of 20% or more in PEFR in group B as compared to just 1 subject in group A . 5 subjects showed atopy in group B while only 1 was atopic in group A. . In both the groups there was a rise in PEFR on exercise initially followed by a fall in PEFR . A good correlation was seen between histamine and exercise oncho–provocation tests. However no relation was seen between Bronchial hyperresponsiveness with atopic status.

Conclusion: A significantly greater incidence of onchial hyperresponsiveness was seen in healthy first degree relative of patients of Bronchial Asthma ..