STUDY OF PREVALENCE OF NONALCOHOLIC FATTY LIVER DISEASE IN ASYMPTOMATIC ADULTS PRESENTING WITH HEPATOMEGALY OR UNEXPLAINED LIVER ENZYME ELEVATIONS

Dr Vevek Rana; Dr Nidhi Anand; Dr Hema Malik

Volume : VII, Issue : XII, December - 2018

STUDY OF PREVALENCE OF NONALCOHOLIC FATTY LIVER DISEASE IN ASYMPTOMATIC ADULTS PRESENTING WITH HEPATOMEGALY OR UNEXPLAINED LIVER ENZYME ELEVATIONS

Dr Vevek Rana, Dr Nidhi Anand, Dr Hema Malik

Abstract :

objectives: To study the prevalence of hepatic steatosis in non alcoholic asymptomatic adults presenting with hepatomegaly or unexplained elevation of liver enzymes with special reference to nonalcoholic steatohepatitis .

Methods: A prospective study was conducted in the department of internal medicine in a tertiary care referral centre in New Delhi , India . 500 cases were selected by random sampling in the age group of 20 to 75 years. Patients were divided into three BMI ( body mass index) Normal :19–25, Overweight : 25–30, Obese :>30. They were further subjected to liver function tests, ultrasound and liver biopsy.

Results: over all prevalence of Non alcoholic fatty liver disease (NAFLD) found in our study was 15 %. Overall prevalence in males was 58.67% and in females was 41.33%. Prevalence of NASH in patients who underwent liver biopsy was 32% and higher in females as compared to males

Conclusion : NAFLD was associated with elevated serum aminotransferases levels in 48.67% of patients . ALT levels were found to be higher than AST levels except in patients with cirrhosis . Out of patients who underwent liver biopsy ,25 in number , 64 % had steatosis, 32% steatohepatitis and 4% had Cirrhosis.