Study of Serum malondialdehyde levels in type 2 diabetics with myocardial infarction

Ruta Anandgaonkar; Dhananjay Bhale; D.M. Vaishnav

Volume : VII, Issue : VIII, August - 2018

Study of Serum malondialdehyde levels in type 2 diabetics with myocardial infarction

Ruta Anandgaonkar, Dhananjay Bhale, D. M. Vaishnav

Abstract :

Introduction:Diabetes mellitus (DM) increases the incidence of cardiovascular diseases (CVDs) (1 , 2) Although elevated levels of serum MDA have been reported in type 2 diabetes, there is paucity of literature on the extent of serum MDA levels in type 2 diabetes cases with myocardial infarction, a macrovascularcomplication.AIMS AND OBJECTIVES:To measure the levels of serum MDA in type 2 diabetes patients with MI and type 2 diabetes patients without complications.Material and Methods:Type 2 diabetics patients of MGM MC .Aurangabad , were selected. They were divided in two groups.Group I: Thirty patients of either sex diagnosed with Type 2 D.M without any complications. Group II: Thirty patients of either sex having type 2 D.M with myocardial infarction. Control :Thirty patients having similar age groups of either sex comprised the control group; they were non–diabetic, non–hypertensive and non–smokers; METHOD:Estimation of MDA was done by thiobarbituric acid reactive substance assay according to the method described by Mahffouz.[12]RESULTS: In both test–groups the serum MDA level were significantly higher as compared with the controls (P< 0.01) and in between the diabetic groups it was found to be significantly higher in diabetes with myocardial infarction (P< 0.01).CONCLUSION :In diabetic patients a major factor that is responsible for enhanced free radical generation is hyperglycemia through auto–oxidation of glucose; it may be an important risk factor for cardiovascular disease.[13]