STUDY OF Serum T3, T4, TSH Level in cases of Type 2 Diabetes Mellitus

Dr. Monika Jayaswal; Dr. Sude Kumar Singh

Volume : VIII, Issue : II, February - 2019

STUDY OF Serum T3, T4, TSH Level in cases of Type 2 Diabetes Mellitus

Dr. Monika Jayaswal, Dr. Sude Kumar Singh

Abstract :

INTRODUCTION Thyroid disorders are also quite common in the general population and it is second only to Diabetes as the most common condition to affect the Endocrine system . As a result it is common for an individual to be affected by both Thyroid Diseases and Diabetes . the first report in this regard was published in 1979 . Thyroid hormones are insulin antagonists , both insulin and Thyroid Hormones are involved in cellular metabolism and excess and deficit in anyone can result in functional derangement of the other . Thyroid disease is a pathological state that adversely affects Diabetes control and is commonly found in most forms of DM which is associated with advanced age in type2 diabetes and Autoimmune diseases in type1 .DM appears to influence Thyroid function in two sites : firstly at the level of Hypothalamic control of TSH release and secondly at the conversion of T4 to T3 in the peripheral tissue . Marked hyperglycemia causes reversible reduction of activity and hepatic concentration of T4– 5 deiodinase , low serum concentration of T3 , Elevated levels of reverse T3 and low , normal or high levels of T4 . It has generally been accepted that the serum T3 level is diminished in patients of type 2 DM referred to as Low T3 Syndrome . , clinically remain Euthyroid . AIMS & OBJECTIVES: 1) To evaluate the actual alternation of serum T3 and T4 and TSH in Patients Of Diabetes Mellitus. 2) To evaluate the utility of screening for thyroid function in clinically Euthyroid. Patients of Diabetes Mellitus who are considered as at risk group with subclinical Hypothyroidism . CONCLUSIONS: From the statistical data it was evident that there was no significant difference between the mean serum T4 levels of control subjects and that of Diabetic PATIENTS . The mean serum T3 levels were similar in GROUP A & B Diabetics but were significantly lower than corresponding ages of control subjects . Thus the Diabetics in the present study although clinically Euthyroid show a low level of circulating T3 to which the term low T3 syndrome has been given .