STUDY OF THYROID DYSFUNCTION IN HIV SEROPOSITIVE PATIENTS ON HIGHLY ACTIVE ANTI RETRO VIRAL THERAPY (HAART)

Dr. Sohan Lal Gora; Dr. Ravindra Kumar Tiwari; Dr. Chandra Kant

Volume : IX, Issue : III, March - 2020

STUDY OF THYROID DYSFUNCTION IN HIV SEROPOSITIVE PATIENTS ON HIGHLY ACTIVE ANTI RETRO VIRAL THERAPY (HAART)

Dr. Sohan Lal Gora, Dr. Ravindra Kumar Tiwari, Dr. Chandra Kant

Abstract :

Background: Subtle alterations in thyroid function tests are more common in HIV infection and at times detectable in the early phase of disease and as well as in late phases. However, there is paucity of Indian studies. Objectives : To study the thyroid dysfunction in newly diagnosed seropositive HIV patients initiating HAART and pattern of change in thyroid profile with measurement at baseline, after 6 and 12 months of HAART and correlation between thyroid function changes in these patients with their CD4 cell count at 0, 6 and 12 months. Methods: Study was included 60 newly diagnosed HIV seropositive patients presenting to JLN Medical College and Hospital, Ajmer (Raj.) and registered at ART Centre JLN Hospital, Ajmer during the period of Jan, 2018 to Oct, 2019 after taking written consent of the patients and the relevant history, these patients were subjected to complete clinical examination. Subjects with HIV serology positive by ELISA test and on HAART regimen were included and Patients with comorbidities eg. T.B., diabetes, CKD, Malignancy, known case of thyroid disorders and patients on drugs that cause thyroid abnormality were excluded. Results: Out of 60 patients included in the study 65% were males and 35% were females. 10% cases were found subclinical hypothyroidism and 3.33% cases were found overt hypothyroidism. In our study correlation between CD4 counts and thyroid dysfunction was found statistically significant (p=0.02). Conclusions: Subclinical hypothyroidism was the most common thyroid abnormality observed followed by overt hypothyroidism. There was statistically significant correlation (negative) between CD4 cell count and thyroid abnormality. Thyroid abnormalities vary with the type and duration of HAART regimen.