Volume : VIII, Issue : IV, April - 2019

Study of toxicity profile of Phenytoin

Dr. Raghavendra Bs, Dr. Pareekshith R Rai

Abstract :

Phenytoin is one of the most commonly used Anti–Epileptic drugs(AEDs). We studied the clinical profile of patients admitted with Phenytoin toxicity. This is a retrospective study of 10 patients diagnosed with Phenytoin toxicity who presented between July 2014 and December 2015. Data on age, sex, duration and dose of phenytoin, concomitant AED use, presenting symptoms, duration of complaints, MRI changes and treatment were recorded. The mean age of patients was 39 years. Nine of the ten patients manifested symptoms at or below 300 mg. The average Phenytoin level was 41.54 mcg/ml. Eight of the ten patients were switched to Levetiracetam and nine of the ten patients recovered. Phenytoin toxicity can develop even at doses of 300 mg daily which is widely used when initiating therapy. This highlights the need to follow up patients, measure plasma levels if required and take steps to reduce risk of toxicity.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

Cite This Article:

STUDY OF TOXICITY PROFILE OF PHENYTOIN, Dr. Raghavendra BS, Dr. Pareekshith R Rai PARIPEX‾INDIAN JOURNAL OF RESEARCH : Volume-8 | Issue-4 | April-2019

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