Study Of Various Biochemical Parameters In �-Thalassemia Major Patients And Its Correlation With Serum Ferritin Level And Transfusion Index

Dr. Ritu Agrawal; Dr. Rajendra Nigam; Dr. Reeni Malik

Volume : VII, Issue : IX, September - 2018

Study Of Various Biochemical Parameters In �-Thalassemia Major Patients And Its Correlation With Serum Ferritin Level And Transfusion Index

Dr. Ritu Agrawal, Dr. Rajendra Nigam, Dr. Reeni Malik

Abstract :

BACKGROUND: Thalassemia is a heterogeneous group of single gene disorder characterized by decreased or absent beta globin chain synthesis, leading to transfusion dependent severe anemia, therapy related iron overload, resulting in many biochemical and metabolic disturbances. OBJECTIVE: The aim of the study was to focus primarily onthe frequency of abnormal lipid profile, serum calcium, phosphorus and alkaline phosphatase and their correlation with serum ferritin level among the β thalassemic major patients on regular blood transfusion in central part of India. METHOD: The study was hospital based crosssectional study in which demographic data as well as history of blood transfusion was taken. Serum lipid profile, calcium and phosphorus, alkaline phosphatase, and serum ferritin level were measured .

RESULT: Out of 60 β thalassemia patients, 37 were male and 23 were female. Total as well HDL and LDL cholesterol were significantly low as compared to reference control group of similar age group, whereas, serum triglyceride levels were significantly high in present study group as compared to reference control group. Hypocalcemia was found in 25% patients. Hyperphosphatemia was found in 22 (36.67%) patients and 2 (3.33%) patients had hyper alkaline phosphatasia. 66% patients of hypocalcemia had hyperphosphatemia simultaneously.

CONCLUSION: Hypocalcemia, hypocholesterolemia and hypertriglyceridemia are more common in second decade of life and should be routinely monitored in thalassemic patients to improve the quality of life and life expectancy of these patients.