Study On Plasma Homocysteine Levels As A Risk Factor In Ischaemic Heart Disease

Dr. Monika Jayaswal; Dr. Sude Kumar Singh

Volume : VIII, Issue : II, February - 2019

Study On Plasma Homocysteine Levels As A Risk Factor In Ischaemic Heart Disease

Dr. Monika Jayaswal, Dr. Sude Kumar Singh

Abstract :

Ischaemic heart disease(IHD) is a condition in which there is an inadequate supplyof blood and oxygen to the myocardium, it typically occurs where there is an imbalance between myocardial oxygen supply and demand. According to WHO fact sheet in 2007, Cardiovascular diseases are the number one cause of death globally. The modifiable risk factors are smoking, hypertension, obesity, dyslipidemia, atherogenic diet, physical inactivituy, diabetes mellitus etc and recently some newer ones are hyperhomocystenemia, prothombotic factors, proinflammatory factors, impaired fasting glucose and subclinical atherosclerosis and lipoprotein(a). Aims and Objectives are to identify the possible risk factors associated to Ischemic heart Diseases, to determine Plasma Homocysteine levels in cases and controls and to assess the relationship between Homocysteine and other previous Parameters. Smokers were found to have more incidence of IHD and stastistically significant. IHD was more common in patients with hypertension, diabetic patients have increased propensity for IHD, mere increased risk of IHD in alcoholics association with age is not commentable but disease was more common in patients with increased body mass index although association was not significant, no causal relationship of hemoglobin with IHD buttotal leucocyte count and ESR was significant higher in patients, patients with IHDhad increased total cholesterol, triglycerides , LDL, and serum homocysteine levelwhich was statistically associated. The mean homocysteine level were higher in obese patients, diabetics, hypertensives, females, patients on mixed diet, hypertension and smokers. Thus our study although validating the view that increased Homocysteine levels are associated with IHD, needs further verificationin larger prospective studies.In conclusion, plasma Homocysteine levels were correlating with IHD and it can be taken as an independent risk factor for IHD.