Synthesis, anti-inflamatory and antibacterial activity of azlactone derivatives

Harshita Goyal; Dr. Alka Pradhan

Volume : VII, Issue : XI, November - 2018

Synthesis, anti-inflamatory and antibacterial activity of azlactone derivatives

Harshita Goyal, Dr. Alka Pradhan

Abstract :

A novel series of 1–(1–{2–hydroxy–R–substituted–5–[(E)–(5–oxo–2– phenyl acetate –1,3–oxazol–4(5H)–ylidene)methyl]phenyl}(phenyl)methyl)–3–[(E)–(4–hydroxy–3–methoxyphenyl) methylidene]thiourea (2a–e) were synthesized by the reaction of 1–[(5–formyl–R–substituted phenyl)(phenyl) methyl]–3–[(E)–(4–hydroxy–3–methoxyphenyl) methylidene] thiourea/urea with acetyl salicyloyl glycine in presence of fused sodium acetate (1.0 g ) and acetic anhydride. The structures of the newly synthesized compounds were established by IR, 1H–NMR, mass spectra and elemental studies. The antibacterial and anti–inflammatory activities of the synthesized compounds were determined. The compounds 3a, 3f, 3h and 3o showed moderate activity.