Synthesis, Characterization and Evaluation of Schiff's Bases of 2-Quinolones.

Dr. Alka Pradhan; Sanjay Kumar Vishwakarma

Volume : IX, Issue : IV, April - 2020

Synthesis, Characterization and Evaluation of Schiff's Bases of 2-Quinolones.

Dr. Alka Pradhan, Sanjay Kumar Vishwakarma

Abstract :

In the present study, we synthesized Schiff bases of quinoline–2–one and their antibacterial activity was evaluated by wells diffusion method. Schiff bases of quinoline–2–one (1 to 8 named as Q2ka–Q2kh) were prepared by refluxing with substituted aromatic ketones. The final test compounds has purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline cl 725. They have evaluated for antibacterial activity. Compounds were active against Klebsiella pneumonia and Enterococcus faecalis. While ciprofloxacin was used as standards.