The comparison of the effects of Fentanyl, Esmolol and Dexmedetomidine for prevention of haemodynamic response to laryngoscopy and endotracheal intubation

Dr. Asha Sharma; Dr Durga Suthar; Dr. S.P.Chittora

Volume : IX, Issue : III, March - 2020

The comparison of the effects of Fentanyl, Esmolol and Dexmedetomidine for prevention of haemodynamic response to laryngoscopy and endotracheal intubation

Dr. Asha Sharma, Dr Durga Suthar, Dr. S. P. Chittora

Abstract :

Introduction : The aim of this study was to evaluate and compare the effects of Fentanyl, Esmolol and Dexmedetomidine for prevention of haemodynamic response to laryngoscopy and endotracheal intubation. Material and method: This study was carried out in 90, ASA grade I and II patients, aged 18 to 60 years who were scheduled for elective surgery under general anaesthesia and were divided into 3 groups of 30 each. Group A– received inj. Dexmedetomidine 1μg/kg diluted to 20 ml with normal saline, Group B – received inj. Fentanyl 2μg/kg, Group C received inj. Esmolol 2 mg/kg IV. Haemodynamic parameters like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, SpO2 were recorded. Results: There was an increase in heart rate, systolic blood pressure, diastolic blood pressure and mean blood pressure during laryngoscopy and after endotracheal intubation in all the groups but increase was minimal in Dexmedetomidine group than Esmolol and Fentanyl group(P<0.05). Conclusion: Dexmedetomidine given 3 minutes prior to laryngoscopy and intubation is safe and more effective than Esmolol and Fentanyl in attenuating the haemodynamic response to direct laryngoscopy and endotracheal intubation.