Volume : IV, Issue : II, February - 2015

Abstract :

Background: Rheumatic mitral stenosis (MS) is a chronic disease with progressive symptoms and adverse hemodynamicconsequences including pulmonary hypertension.In patients with severe mitral stenosis the increased right ventricle (RV) after load causes RV hypertrophy suggested to impair the coronary blood flow and might lead to cardiac dysfunction. Methods: patients with severe mitral valve stenosis underwent coronary angiography, cardiac catheterization and echocardiography to evaluate the TIMI frame count, hemodynamic data. Patients with significant valvular involvement other than mitral stenosis, significant ventricular dysfunction and coronary stenosis were excluded. Results: The mean age of the patients was 49.5±12.7 years and 73.5 % of patients were female.The corrected TIMI frame counts were significantly higher in all vessels compared with normal values (p<0.001) and difference between RCA TFC and its normal value was significantly higher than difference between LCX TFC and LAD TFC with their normal values. Moreover, significant positive correlation observed between mean RCA TFC and systolic and diastolic PAP (p=0.02 & 0.014 respectively). Conclusion: the increased TFC in patients with mitral stenosis may be the result of natural progression of disease or atrial fiillation. Moreover, reduced flow in RCA and its relation with PAP is justified with ventricular hypertrophy and increased vascular resistance or endothelial dysfunction.

Article: Download PDF    DOI : https://www.doi.org/10.36106/paripex  

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, PARIPEX-INDIAN JOURNAL OF RESEARCH : Volume-2 | Issue-3 | March-2013

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