The Difference of Insulin-Like Growth Factor 1 Receptor Expression in Breast Cancer Patients Who Are Suffering and Not Diabetes Mellitus Type 2 in Adam Malik Hospital

Rafki Hidayat; Kamal Basri Siregar; Suyatno

Volume : IX, Issue : I, January - 2020

The Difference of Insulin-Like Growth Factor 1 Receptor Expression in Breast Cancer Patients Who Are Suffering and Not Diabetes Mellitus Type 2 in Adam Malik Hospital

Rafki Hidayat, Kamal Basri Siregar, Suyatno

Abstract :

Background: Breast cancer is a global problem and a prominent international health issue, including the most common malignancies in women in developed countries. Like east cancer, diabetes mellitus (DM) is still a global problem, especially in developed countries. This study would like to see the difference of insulin–like growth factor 1 receptor expression in diabetic east cancer patients and non–diabetic east cancer patients. Methods: The design of this study is case–control, with the patients included in this study are the east cancer patients with or without a history of type 2 DM who already had an examination of insulin growth factor (IGF) histopathology. The statistical analysis was done with chi–square analysis to determine the relationship between the overexpression of the IGF1 receptor (IGF1R) and the history of type 2 diabetes mellitus (DM). Result: There was a statistically significant difference between the overexpression of the IGF1R incident and a history of type 2 DM in a patient with east cancer (p = 0.001, OR: 4.9; 95% CI 1.898 – 12.697). Further analysis of the sample characteristics also showed a significant difference between the overexpression of IGF1R incident and the incident of distant metastasis (p = 0.049). Conclusion: In this study, it was found that there was a significant difference in the expression of IGF1R in east cancer patients suffering from and not type 2 diabetes mellitus; and could be a predictor of east cancer, especially in patients with diabetes mellitus.