THE IMPACT OF CD4 IN EVOLUTION OF PARASITIC DIARRHOEA IN SEROPOSITIVE PATIENTS

Dr. Somya Sinha; Dr. (Prof.) Prabhu Prakash

Volume : VIII, Issue : XII, December - 2019

THE IMPACT OF CD4 IN EVOLUTION OF PARASITIC DIARRHOEA IN SEROPOSITIVE PATIENTS

Dr. Somya Sinha, Dr. Prof. Prabhu Prakash

Abstract :

Human immunodeficiency virus (HIV) infection has altered both the epidemiology and outcome of enteric opportunistic parasitic infections. This study was done to determine the prevalence and species/genotypes of intestinal coccidian and microsporidial infections among HIV/AIDS patients with diarrhea and/or a history of diarrhea alternately with an asymptomatic interval, and their association with CD4 T cell count. This crosssectional study was done from May 2016 to March 2017 in Sampurnanand Medical College and Hospital,Jodhpur. A blood sample was obtained from HIV–positive patients for a CD4 T cell count upon enrollment. Sociodemographic data and a history of diarrhea were collected by interviewing 195 consecutive participants ( 116 males and 79 females).Using routine microscopy ,trichrome staining,modified ZN staining incidence of coccidian parasites were found to be as Cryptosporidium 21.8% ,followed by Strongyloides 17.6% ,microsporidia ,Isospors , Giardia ,Trichuris ,and taenea . A CD4 count < 200 cells/ll was significantly associated with the presence of opportunistic parasites and diarrhea ( p < 0.05). Opportunistic intestinal parasites should be suspected in any HIV/AIDS patient with chronic diarrhea.