The serological picture of inadequate response to red cells in the multitransfused population in Eastern India.

Dr. Durba Biswas; Dr. Prasun Bhattacharya

Volume : VIII, Issue : V, May - 2019

The serological picture of inadequate response to red cells in the multitransfused population in Eastern India.

Dr. Durba Biswas, Dr. Prasun Bhattacharya

Abstract :

BACKGROUND: Inadequate response to red cell transfusion due to isoimmunisation is common in multitransfused patients. AIMS: This study aimed to analyse the serological picture and formulate a reasonable approach in these multitransfused patients. METHODS: This is a prospective study carried over six months on the multitransfused patients referred to the transfusion medicine department of a tertiary care hospital. RESULTS: There were 147 patients observed, 77 patients were found to be allo/auto–immunised. A majority of them were females[71.43%] and within 20–40 years[46.75%] age group. In 69 of the 77 immunised patients, 38 were positive to both DAT and antibody screen while 31 were only DAT positive; rest 8 patients were only antibody screen positive. A total of 42 antibodies could be identified with ‘Anti–E’ (38.09%) being the commonest. CONCLUSION: DAT positivity is a sensitive marker of isoimmunisation. The practice of routine immunohematological workup may prevent certain adverse outcomes.