THROMBOCYTOPENIA AS THE IMPORTANT PROGNOSTIC MARKER OF SEPSIS

D CHAITANYA REDDY; NAGESH KUMAR TC; ANIL KUMAR; RASHMI K

Volume : VIII, Issue : VII, July - 2019

THROMBOCYTOPENIA AS THE IMPORTANT PROGNOSTIC MARKER OF SEPSIS

D Chaitanya Reddy, Nagesh Kumar Tc, Anil Kumar, Rashmi K

Abstract :

BACKGROUND: Sepsis is currently a major concern globally. Assessing the prognosis of sepsis remains difficult even after the availability of several biomarkers. The simple platelet counts monitoring may be very useful for assessing the patients with sepsis. A significant drop in platelet count can be used as independent prognostic factor in sepsis. AIM OF THE STUDY: (1) To compare the prognostic factors between the thrombocytopenic and non thrombocytopenic patients of sepsis. (2) To correlate the platelet count with APACHE II (Acute Physiology and Chronic Health Evaluation) scores during the ICU (intensive care unit) stay of sepsis patients. MATERIALS AND METHODS: This is the prospective study done on 138 patients admitted to the ICU, diagnosed to have sepsis during the period September 2014 to June 2016 were included in this study. APACHE II score and platelet count monitored during ICU stay. Patients were divided in to two groups (with thrombocytopenia and without thrombocytopenia). Outcome of the patients in both the groups were compared. RESULTS: Mortality rate of sepsis in the study was 54.3%. Mortality among thrombocytopenia group is 73.6% compared to patient without thrombocytopenia (33.3%). Patients with thrombocytopenia had higher mean APACHEII score (14.69) compared with other group (12.08). Among patients with low platelet count, drop in platelet >50% is associated with increased mortality (85%). Thrombocytopenia group had long duration of ICU stay compared to patient without thrombocytopenia. CONCLUSION: Thrombocytopenia was shown to be indicator of poor prognosis. Progression of thrombocytopenia indicated by drop in platelet count >50% is associated with significant mortality, longer ICU stay and higher APACHE II score.