TO COMPARE CLINICAL EFFICACY OF CLONIDINE AND FENTANYL AS ADJUVANT IN SUB-ARACHNOID BLOCK FOR ABDOMINAL HYSTERECTOMY

Dr.P.S.Gandhi; Dr. Sourabh Jain; Dr. Sadhana Sanwatsarkar; Dr. RajBhan Singh; Dr. Swati Sharma; Dr. Tanya Chhauda

Volume : VII, Issue : IV, April - 2018

TO COMPARE CLINICAL EFFICACY OF CLONIDINE AND FENTANYL AS ADJUVANT IN SUB-ARACHNOID BLOCK FOR ABDOMINAL HYSTERECTOMY

Dr. P. S. Gandhi, Dr. Sourabh Jain, Dr. Sadhana Sanwatsarkar, Dr. Rajbhan Singh, Dr. Swati Sharma, Dr. Tanya Chhauda

Abstract :

AIM AND OBJECTIVES–The aim of this study was to assess the onset and duration, level of sensory and motor block, hemodynamic parameters and adverse effects of combination of clonidine and fentanyl given intrathecallywith hyperbaric 0.5% bupivacaine.MATERIAL AND METHODS: In this Prospective, double blind study 120 patients posted for TAH were randomized into fourgroups.Group B received (0.5% Hyperbaric Bupivacaine 3.5 ml),Group BC received (0.5% Hyperbaric Bupivacaine 3.0 ml + clonidine 30 mcg with saline 0.3 ml )Group BF received (0.5% Hyperbaric Bupivacaine 3.0 ml+ Fentanyl 15mcgs with saline 0.2 ml )Group BCF (0.5% Hyperbaric Bupivacaine 3.0 ml with clonidine 30 mcg and fentanyl 15mcgs ).The onset and duration of sensory and motor block, hemodynamic parameters and the incidence of side effects in all four groups were noted and compared.RESULT–Significant prolongation of duration of sensory and motor block was found in group BCF. Fall in mean BP and heart rate was seen in BCF group at clinically acceptable levels without significant adverse effects.CONCLUSION– Addition of low dose clonidine and fentanyl together intrathecally prolongs motor and sensory block, compared to fentanyl or clonidine alone as adjuvant to Bupivacaine without any hemodynamic instability.