To Study the Relationship Between Serum Vitamin D3 Level and Diabetic Nephropathy in Type2 Diabetes Mellitus Subject

Dr. C. P. Meena; Dr.Hemant Kumar Richhariya

Volume : VIII, Issue : V, May - 2019

To Study the Relationship Between Serum Vitamin D3 Level and Diabetic Nephropathy in Type2 Diabetes Mellitus Subject

Dr. C. P. Meena, Dr. Hemant Kumar Richhariya

Abstract :

Introduction & Objective: – To estimate & study the relationship between serum vitamin D3 level and diabetic nephropathy in type2 diabetes mellitus subject. The studies evaluating the role of vitamin D3 in Diabetic Nephropathy are few. Material and Methods: – A total of 100 patients with type2 diabetes mellitus were enrolled from inpatients of our hospital. Out of which 50 patients with and 50 patients without Diabetic Nephropathy were considered. Serum vitamin D3 and 24 hour urinary albumin excretion rate were investigated and analysed. Nephropathy is defined as 24hour urinary albumin excretion >30 mg. Serum vitamin D3 levels were characterized as <20 ng/mL vitamin D3 deficiency, 20 to 29 ng/mL vitamin D3 insufficiency and >30 ng/mL normal vitamin D3. Results: – Overall, the urinary albumin excretion rate was significantly higher in patients with vitamin D3 deficiency than with normal vitamin D3 level {(122+29.2)mg/24hr vs. (41.6+8.1)mg/24hr}. 48% of adults with type2 diabetes mellitus have vitamin D3 deficiency and 27% have vitamin D3 insufficiency. Higher proportions of individuals with nephropathy have vitamin D3 deficiency than individuals without nephropathy; 43% vs. 32% (odds ratio, 2.95; 95% CI, 1.14 –7.64, P= 0.0257). Logistic regressions demonstrate vitamin D3 deficiency and insufficiency are associated with the presence of nephropathy after adjustment for age, sex, hypertension, lipid profile, smoking and use of angiotensin–converting enzyme(ACE) inhibitors or angiotensin receptor Blockers(ARBs) (odds ratio, 3.60; 95% CI, 1.25 –10.23 for vitamin D3 deficiency; and odds ratio, 3.21; 95% CI, 1.01–10.22 for vitamin D3 insufficiency). Conclusion: – There is a high prevalence of vitamin D3 deficiency in individuals of type 2 DM with Diabetic Nephropathy. Thus, evaluating vitamin D3 levels in people with Diabetic Nephropathy may be warranted. There is an independent association between vitamin D3 deficiency with the presence of nephropathy