Transitional cell carcinoma arising in giant hydronephrosis due to congenital ureteropelvic junction obstruction; five cases experience at IGIMS

Dr.Khalid Mahmood; Dr.Ahsan Ahmad; Dr.Vishrut Bharti

Volume : VIII, Issue : VI, June - 2019

Transitional cell carcinoma arising in giant hydronephrosis due to congenital ureteropelvic junction obstruction; five cases experience at IGIMS

Dr. Khalid Mahmood, Dr. Ahsan Ahmad, Dr. Vishrut Bharti

Abstract :

Objectives: transitional cell carcinoma( TCC) developing in giant hydronephrosis which is an extremely rare entity. Most urologists are not familiar with it. Here, we present our experience with five cases of this disease and a review of literature. Materials and Methods: This is a retrospective study in a tertiary care center (IGIMS, Patna, Bihar, India) from January 2013 to Feuary 2019. Results: All the patients were in their fourth to sixth decades of life. large cystic abdominal lump and history of hematuria. was the most common presentation. On evaluation, they were diagnosed as a case of ureteropelvic junction obstruction(UPJO) with giant hydronephrosis and multiple papillary enhancing lesions in renal pelvis. Patients underwent radical nephroureterectomy. Histopathological analysis confirmed the presence of transitional cell carcinoma of renal pelvis. Conclusion: Longstanding giant hydronephrosis in cases of UPJO might be a risk factor of developing TCC of renal pelvis